Description:σ1selectiveagoNISTChemicalName:(2S,6S,11S)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(2-propenyl)-2,6-methano-3-benzazocin-8-olhydrochloridePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityPrototypicalσ1receptoragonist.Behaviorallyactiveinanimalmodelsofmemoryandstress.TechnicalDataM.Wt293.84FormulaC17H23NO.HClStorageDesiccateat+4°CPurity≥98%(HPLC)CASNumber133005-41-1PubChemID16759596InChIKeyCFMYXEVWODSLAX-CKYAAQHSSA-NSmilesOC1=CC=C2C([C@@](CC3)(C)[C@H](C)[C@@H](N3CC=C)C2)=C1.ClThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO29.38100water29.38100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight293.84.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM3.4mL17.02mL34.03mL5mM0.68mL3.4mL6.81mL10mM0.34mL1.7mL3.4mL50mM0.07mL0.34mL0.68mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Kameietal(1996)(+)-SKF-10,047anddextromethorphanameliorateconditionedfearstressviadopaminergicsystemslinkedtophenytoin-regulatedσ1sites.Eur.J.Pharmacol.309149PMID:8874133Matsunoetal(1995)Involvementofσ1receptorin(+)-N-allylnormetazocine-stimulatedhippocampalcholinergicfunctionsinrats.BrainRes.690200PMID:8535837Walkeretal(1990)Sigmareceptors:biologyandfunction.Pharmacol.Rev.42355PMID:1964225Keywords:(+)-SK&F10047hydrochloride,supplier,σ1,sigma1,selective,agonists,Receptors,σ,sigma,(+)-SK&F10047,SK&F10047,hydrochloride,SKF10047,(+)-SK&F,10047,SK&F10047,Sigma1,Receptors,Sigma1,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
