产品说明
Description:HighaffinityandselectiveCB2inverseagoNISTChemicalName:5-(4-Chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamidePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityHighaffinityandselectiveCB2inverseagonist(Ki=0.6nM).Exhibits>700-foldselectivityforCB2overCB1receptors.BlockstheeffectsofCP55,940(Cat.No.0949)onforskolin-sensitiveadenylylcyclaseactivityandMAPKinCHOcellsexpressingCB2receptors.AlsoblocksCP55,940-inducedB-cellactivation.Orallybioavailable.TechnicalDataM.Wt476.05FormulaC29H34ClN3OStorageStoreat-20°CPurity≥98%(HPLC)CASNumber192703-06-3PubChemID3081355InChIKeySUGVYNSRNKFXQM-XRHWURSXSA-NSmilesC[C@]1(C2)[C@H](NC(C3=NN(CC4=CC=C(C)C=C4)C(C5=CC=C(Cl)C(C)=C5)=C3)=O)C(C)(C)[C@@H]2CC1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO47.6100ethanol47.6100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight476.05.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.1mL10.5mL21.01mL5mM0.42mL2.1mL4.2mL10mM0.21mL1.05mL2.1mL50mM0.04mL0.21mL0.42mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Rinaldi-Carmonaetal(1998)SR144528,thefirstpotentandselectiveantagonistoftheCB2cannABInoidreceptor.J.Pharmacol.Exp.Ther.284644PMID:9454810Kotsikorouetal(2013)TheimportanceofhydrogenbondingandaromaticstackingtotheaffinityandefficacyofcannabinoidreceptorCB2antagonist,5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethJ.Med.Chem.566593PMID:23855811Bouaboulaetal(1999)GiproteinmodulationinducedbyaselectiveinverseagonistfortheperipheralcannabinoidreceptorCB2:implicationforintracellularsignalizationcross-regulation.Mol.Pharmacol.55473PMID:10051530Keywords:SR144528,supplier,SR144528,high,affinity,selective,cannabinoid,receptors,CB2,inverse,agonists,orally,bioavailable,immunology,CB2,Receptors,CB2,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
新品排行榜
1
Tocris/Cardamonin/2509/10/10 mg
2
Tocris/TG 100713/4264/10/10 mg
3
Tocris/SB 3CT/6088/10/10 mg
4
Tocris/rac BHFF/3313/50/50 mg
5
Tocris/Cardamonin/2509/50/50 mg
6
Tocris/BAM 15/5737/50/50 mg
7
Tocris/PF 04217903 mesylate/4239...
8
Tocris/α-Amanitin/4025/1/1 ...
9
Tocris/GBR 12783 dihydrochloride...
10
Tocris/BAM 7/4810/10/10 mg
文章排行榜
1
novus抗体-价格-采购-供应商信息-丁香通
2
Tocris/(RS)-3-Hydroxyphenylglycine/0324/50/50 mg
3
Tocris/SCH 442416/2463/10/10 mg
4
Tocris Bioscience部分产品7.5折促销
5
小分子 | Tocris 生物科学,tocris产品目录
6
Tocris/VUF 11207 fumarate/4780/50/50 mg
7
Tocris/CGP 54626 hydrochloride/1088/10/10 mg
8
Tocris/JNJ 10181457 dihydrochloride/4019/10/10 mg
9
Tocris/VUF 11222/5668/10/10 mg
10
关于 Tocris | Tocris 生物科学,Tocris/SB 265610/2724/1/1 mg
