首页 > Tocris > Tocris/WIN 55,212-2 mesylate/1038/50/50 mg

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Tocris/WIN 55,212-2 mesylate/1038/50/50 mg

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1038/50

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Tocris

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Description:HighlypotentcannABInoidreceptoragoNISTAlternativeNames:(R)-(+)-WIN55212ChemicalName:(R)-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanonemesylatePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityNanomolaraffinitycannabinoidreceptoragonist(Kivaluesare62.3and3.3nMatthehumanclonedCB1andCB2receptorsrespectively).S-enantiomerWIN55,212-3mesylate(Cat.No.2327)alsoavailable.TechnicalDataM.Wt522.61FormulaC27H26N2O3.CH3SO3HStorageStoreat+4°CPurity≥98%(HPLC)CASNumber131543-23-2PubChemID6604176InChIKeyFSGCSTPOPBJYSX-VEIFNGETSA-NSmilesCS(O)(=O)=O.CC1=C(C(=O)C2=CC=CC3=C2C=CC=C3)C2=CC=CC3=C2N1[C@H](CN1CCOCC1)CO3Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO52.26100mMwithgentlewarmingethanol15.6830mMwithgentlewarmingPreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight522.61.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM1.91mL9.57mL19.13mL5mM0.38mL1.91mL3.83mL10mM0.19mL0.96mL1.91mL50mM0.04mL0.19mL0.38mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.D'Ambraetal(1992)Conformationallyrestrainedanaloguesofpravadoline:nanomolarpotent,enantioselective,(aminoalkyl)indoleagonistsofthecannabinoidreceptor.J.Med.Chem.35124PMID:1732519Felderetal(1995)ComparisonofthepharmacologyandsignaltransductionofthehumancannabinoidCB1andCB2receptors.Mol.Pharmacol.48443PMID:7565624Griffinetal(1998)Evaluationofcannabinoidreceptoragonistsandantagonistsusingtheguanosine-5'-O-(3-[35S]thio)-triphosphatebindingassayinratcerebellarmembranes.J.Pharmacol.Exp.Ther.285553PMID:9580597Martellottaetal(1998)Self-administrationofthecannabinoidreceptoragonistWIN55,212-2indrugnaivemice.Neuroscience85327PMID:9622233Keywords:WIN55,212-2mesylate,supplier,potent,cannabinoid,agonists,Non-Selective,Cannabinoids,Receptors,WIN55212-2,mesylate,(R)-(+)-WIN55212,cb2r,cb1r,WIN552122,(R)-(+)-WIN,55212,Non-selective,Cannabinoids,Non-selective,Cannabinoids,TocrisBioscience

Tocris Bioscience.png

Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。

Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。

Tocris Bioscience的主要产品包括：

Small Molecules

Peptides

Aptamers

Controlled Substances

Compound Libraries

DREADD Ligands

Fluorescent Imaging

Ligand Sets

Optopharmacology

Reagents

Toxins