Description:CB2antagoNIST/CB1partialinverseagonist;enantiomerofWIN55,212-2(Cat.No.1038)AlternativeNames:(S)-(-)-WIN55,212ChemicalName:[(3S)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanonemonomethanesulfonatePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityNovel,lowpotencyCB2receptorsilentantagonistandCB1receptorpartialinverseagonist.CompetitivelyantagonizeseffectsofCP55,940(pA2=6.1)andSR144528(pEC50=5.3)atCB2receptorsandactsasapartialinverseagonistatCB1receptors(pIC50=5.5).DisplaysmodestactivityathumanmelatoninMT1andmuscarinicM4receptors,butisselectiveoverseveralotherGPCRs.TechnicalDataM.Wt522.61FormulaC27H26N2O3.CH3SO3HStorageStoreat+4°CPurity≥98%(HPLC)CASNumber131543-25-4PubChemID11613341InChIKeyFSGCSTPOPBJYSX-BDQAORGHSA-NSmilesCS(O)(=O)=O.CC1=C(C(=O)C2=CC=CC3=C2C=CC=C3)C2=CC=CC3=C2N1[C@@H](CN1CCOCC1)CO3Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO52.26100mMwithgentlewarmingPreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight522.61.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM1.91mL9.57mL19.13mL5mM0.38mL1.91mL3.83mL10mM0.19mL0.96mL1.91mL50mM0.04mL0.19mL0.38mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Savinainenetal(2005)IdentificationofWIN55212-3asacompetitiveneutralantagonistofthehumancannABInoidCB2receptor.Br.J.Pharmacol.145636PMID:15852035Keywords:WIN552,12-3mesylate,supplier,CB2,antagonists,CB1,partial,inverse,agonists,cannabinoids,Non-Selective,Receptors,WIN552123,mesylate,(S)-(-)-WIN55212,cb2r,cb1r,(S)-(-)-WIN,55,212,Non-selective,Cannabinoids,Non-selective,Cannabinoids,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
