Description:BenzodiazepineagoNISTChemicalName:N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamidePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityBenzodiazepineagonistwithhighselectivityforα1-subunit-containingGABAAreceptors(BZ/ω1site)andveryhighintrinsicactivity.Kivaluesare20,400and≥5000nMforα1-,α2-/α3-,andα5-containingGABAAreceptorsrespectively.Hypnoticthatdoesnotinducephysicaldependence.TechnicalDataM.Wt307.39FormulaC19H21N3OStorageStoreatRTPurity≥99%(HPLC)CASNumber82626-48-0PubChemID5732InChIKeyZAFYATHCZYHLPB-UHFFFAOYSA-NSmilesO=C(N(C)C)CC1=C(C3=CC=C(C)C=C3)N=C2N1C=C(C)C=C2Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO15.3750ethanol30.74100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight307.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM3.25mL16.27mL32.53mL5mM0.65mL3.25mL6.51mL10mM0.33mL1.63mL3.25mL50mM0.07mL0.33mL0.65mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Arbillaetal(1986)Highaffinity[3H]zolpidembindingintheratbrain:animidazopyridinewithagonistpropertiesatcentralbenzodiazepinereceptors.Eur.J.Pharmacol.130257PMID:2878820Crestanietal(2000)Mechanismofactionofthehypnoticzolpideminvivo.Br.J.Pharmacol.1311251PMID:11090095Depoortereetal(1986)Zolpidem,anovelnonbenzodiazepinehypnotic.1.Neuropharmacologicalandbehaviouraleffects.J.Pharmacol.Exp.Ther.237649PMID:2871178Perraultetal(1992)Lackoftoleranceandphysicaldependenceuponrepeatedtreatmentwiththenovelhypnoticzolpidem.J.Pharmacol.Exp.Ther.263298PMID:1403792Keywords:Zolpidem,supplier,Benzodiazepine,agonists,GABAA,Receptors,GABAA,Receptors,GABAA,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
