Description:BenzodiazepineagoNISTChemicalName:4-Methyl-1-piperazinecarboxylicacid6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-ylesterPurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityAnonbenzodiazepineBZRagonist,withlittledifferenceinaffinityfortheBZ1andBZ2subtypes;howeveritsCNSeffectsdifferfromthoseofotherBZRligandsandthismaybeduetointeractionwithadifferentsubunit.TechnicalDataM.Wt388.81FormulaC17H17ClN6O3StorageStoreatRTPurity≥99%(HPLC)CASNumber43200-80-2PubChemID5735InChIKeyGBBSUAFBMRNDJC-UHFFFAOYSA-NSmilesCN1CCN(CC1)C(=O)OC1N(C(=O)C2=NC=CN=C12)C1=CC=C(Cl)C=N1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO29.1675PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight388.81.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.57mL12.86mL25.72mL5mM0.51mL2.57mL5.14mL10mM0.26mL1.29mL2.57mL50mM0.05mL0.26mL0.51mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.GoaandHeel(1986)Zopiclone.Areviewofitspharmacodynamicandpharmacokineticproperties,andtherapeuticefficacyasahypnotic.Drugs3248PMID:2874974Imetal(1993)Potentiationofγ-aminobutyricacidinducedchloridecurrentsbyvariousbenzodiazepinesiteagonistswiththeα1γ2,β2γ2andα1β2γ2subtypesofclonedγ-aminobutyricacidtypeAreceptors.Mol.Pharmacol.44866PMID:7901754Munakataetal(1996)Heterogeneousdistributionofbenzodiazepinereceptorsamongratneostriatalneurones.Br.J.Pharmacol.118820PMID:8762113Keywords:Zopiclone,supplier,Benzodiazepine,agonists,GABAA,Receptors,GABAA,Receptors,GABAA,Receptors,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
