首页 > Tocris > Tocris/(Z)-4-Hydroxytamoxifen/3412/50/50 mg

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Tocris/(Z)-4-Hydroxytamoxifen/3412/50/50 mg

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3412/50

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Tocris

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Description:Metaboliteoftamoxifen(Cat.No.0999)AlternativeNames:4-OH-TAMChemicalName:4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenolPurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityEstrogenreceptorantagoNIST.Tamoxifen(Cat.No.0999)metabolite;exhibitsgreaterpotencythantheparentcompound.Chemotherapeuticagent.Alsoactivatesintein-linkedinactiveCas9,reducingoff-targetCRISPR-mediatedgeneediting;systemhas~25-foldhigherspecificitythanwtCas9.TechnicalDataM.Wt387.51FormulaC26H29NO2StorageStoreat+4°CPurity≥98%(HPLC)CASNumber68047-06-3PubChemID449459InChIKeyTXUZVZSFRXZGTL-QPLCGJKRSA-NSmilesCCC(C3=CC=CC=C3)=C(C2=CC=C(OCCN(C)C)C=C2)/C1=CC=C(O)C=C1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO38.75100ethanol19.3850PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight387.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.58mL12.9mL25.81mL5mM0.52mL2.58mL5.16mL10mM0.26mL1.29mL2.58mL50mM0.05mL0.26mL0.52mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Jordanetal(1977)Amonohydroxylatedmetaboliteoftamoxifenwithpotentantioestrogenicactivity.J.Endocrinology75305PMID:591813Destaetal(2004)ComprehensiveevaluationoftamoxifensequentialbiotransformationbythehumancytochromeP450systeminvitro:ProminentrolesforCYP3AandCYP2D6.J.Pharm.Exp.Ther.3101062PMID:15159443YuandForman(2003)Simpleandefficientproductionof(Z)-4-hydroxytamoxifen,apotentestrogenreceptormodulator.J.Org.Chem.689489PMID:14629178Davisetal(2015)Smallmolecule-triggeredCas9proteinwithimprovedgenome-editingspecificity.Nat.Chem.Biol.11316PMID:25848930Keywords:(Z)-4-Hydroxytamoxifen,supplier,estrogen,receptors,antagonists,ER,4-hydroxy-TAM,antiestrogens,antioestrogens,SERM,selective,modulators,CRISPR,Cas9-intein,4-OH-TAM,Estrogen,and,Related,Receptors,CRISPR,Reagents,Estrogen,and,Related,Receptors,TocrisBioscience

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Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。

Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。

Tocris Bioscience的主要产品包括：

Small Molecules

Peptides

Aptamers

Controlled Substances

Compound Libraries

DREADD Ligands

Fluorescent Imaging

Ligand Sets

Optopharmacology

Reagents

Toxins