Description:SelectivePARP-3inhibitorChemicalName:3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamidePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityInhibitorofPARP-3(IC50=0.89μM).DisplaysselectivityforPARP-3overPARP-1,PARP-2andotherARDTenzymes(IC50valuesare6.3,10.8and>30μMrespectively).EnhancesCRISPR-Cas9-mediatedHER2mutationfrequency,resultinginincreasedreductioninproliferationofHER2-positivebreastcancercells.Cellpermeable.CompoundLibrariesME0328isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.TechnicalDataM.Wt321.37FormulaC19H19N3O2StorageStoreat+4°CPurity≥98%(HPLC)CASNumber1445251-22-8PubChemID71571526InChIKeyQIHBWVVVRYYYRO-ZDUSSCGKSA-NSmilesO=C2NC(CCC(N[C@@H](C)C3=CC=CC=C3)=O)=NC1=CC=CC=C12Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO32.14100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight321.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM3.11mL15.56mL31.12mL5mM0.62mL3.11mL6.22mL10mM0.31mL1.56mL3.11mL50mM0.06mL0.31mL0.62mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Lindgrenetal(2013)PARPinhibitorwithselectivitytowardADP-ribosyltransferaseARTD3/PARP3.ACSChem.Biol.81698PMID:23742272WangandSun(2016)CRISPR-mediatedtargetingofHER2inhibitscellproliferationthroughadominantnegativemutation.CancerLett.PMID:27815036Keywords:ME0328,supplier,ME0328,PARP3,ARDT3,inhibitors,inhibits,selective,CRISPR-Cas9,HER2,Poly(ADP-ribose),Polymerase,CRISPR,Reagents,Poly(ADP-ribose),Polymerase,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
