首页 > Tocris > Tocris/NU 7441/3712/50/50 mg

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Tocris/NU 7441/3712/50/50 mg

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3712/50

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Tocris

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Description:PotentandselectiveDNA-PKinhibitorAlternativeNames:KU57788ChemicalName:8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-onePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityPotentandselectiveDNA-PKinhibitor(IC50=14nM).SelectiveforDNA-PKoverarangeofkinasesincludingmTOR,PI3-K,ATMandATR.Potentiatestheeffectsofdoxorubicin(Cat.No.2252)andetoposide(Cat.No.1226)invitroandetoposideinvivo.AlsoenhancesCRISPR-Cas9-mediatedhomology-directedrepair(HDR)efficiency2to3-fold,anddecreasesnonhomologousend-joining(NHEJ)frequency~40%.TechnicalDataM.Wt413.49FormulaC25H19NO3SStorageStoreat+4°CPurity≥99%(HPLC)CASNumber503468-95-9PubChemID11327430InChIKeyJAMULYFATHSZJM-UHFFFAOYSA-NSmilesO=C1C3=C(C(C4=CC=CC5=C4SC6=C5C=CC=C6)=CC=C3)OC(N2CCOCC2)=C1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO2.075mMwithgentlewarmingPreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight413.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.42mL12.09mL24.18mL5mM0.48mL2.42mL4.84mL10mM0.24mL1.21mL2.42mL50mM0.05mL0.24mL0.48mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Zhaoetal(2006)PreclinicalevaluationofapotentnovelDNA-dependentproteinkinaseinhibitorNU7441.CancerRes.665354PMID:16707462Willmoreetal(2008)DNA-dependentproteinkinaseisatherapeutictargetandanindicatorofpoorprognosisinB-cellchroniclymphocyticleukemia.Clin.CancerRes.143984PMID:18559621Leahyetal(2004)IdentificationofahighlypotentandselectiveDNA-dependentproteinkinase(DNA-PK)inhibitor(NU7441)byscreeningofchromenonelibraries.Bioorg.Med.Chem.Lett.146083PMID:15546735Robertetal(2015)PharmacologicalinhibitionofDNA-PKstimulatesCas9-mediatedgenomeediting.GenomeMed.793PMID:26307031Keywords:NU7441,supplier,potent,selective,DNA-dependent,protein,kinases,inhibitors,inhibits,Checkpoint,Control,Kinases,DNA-PK,NU7441,KU57788,CRISPR,Cas9,HDR,NHEJ,homology,directed,repair,nonhomologous,end,joining,KU,57788,DNA-dependent,Protein,Kinase,Checkpoint,Control,Kinases,CRISPR,Reagents,DNA-dependent,Protein,Kinase,TocrisBioscience

Tocris Bioscience.png

Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。

Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。

Tocris Bioscience的主要产品包括：

Small Molecules

Peptides

Aptamers

Controlled Substances

Compound Libraries

DREADD Ligands

Fluorescent Imaging

Ligand Sets

Optopharmacology

Reagents

Toxins