首页 > Tocris > Tocris/SCR7 pyrazine/5342/50/50 mg

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Tocris/SCR7 pyrazine/5342/50/50 mg

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5342/50

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Tocris

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Description:EnhancesHDRefficiencyChemicalName:2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinonePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityEnhancesCRISPR-Cas9-mediatedhomology-directedrepair(HDR)efficiencyinvitroupto19-fold.Inhibitsnonhomologousend-joining(NHEJ).WehavediscoveredthatthecommerciallyavailableSCR7materialsuppliedbyothervendorsdoesnotmatchthechemicalstructurethatitisbeingsoldunder.ThroughdetailedchemicalanalysiscarriedoutbyourAnalyticalQualityControlexperts,webelievethatthecommerciallyavailableSCR7material,includingthatusedinrecentpublicationstoenhanceCRISPRefficiency,isinfactananalogofSCR7thatwehavenamed'SCR7pyrazine'.ViewmoreinformationregardingthestructureofSCR7.TechnicalDataM.Wt332.38FormulaC18H12N4OSStorageStoreat+4°CPurity≥98%(HPLC)CASNumber14892-97-8PubChemID10688007InChIKeyGSRTWXVBHGOUBU-UHFFFAOYSA-NSmilesO=C(C(N=C(C3=CC=CC=C3)C(C4=CC=CC=C4)=N2)=C2N1)NC1=SThetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO33.44100ethanol6.6920PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight332.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM3.01mL15.04mL30.09mL5mM0.6mL3.01mL6.02mL10mM0.3mL1.5mL3.01mL50mM0.06mL0.3mL0.6mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Chuetal(2015)Increasingtheefficiencyofhomology-directedrepairforCRISPR-Cas9-inducedprecisegeneeditinginmammaliancells.Nat.Biotechnol.33543PMID:25803306Maruyamaetal(2015)IncreasingtheefficiencyofprecisegenomeeditingwithCRISPR-Cas9byinhibitionofnonhomologousendjoining.Nat.Biotechnol.33538PMID:25798939Grecoetal(2016)SynthesisandstructuredeterminationofSCR7,aDNAligaseinhibitorTeterahedronLett.573204PMID:Grecoetal(2016)SCR7isneitheraselectivenorapotentinhibitorofhumanDNAligaseIV.DNARepair(Amst)4318PMID:27235626Keywords:SCR7pyrazine,supplier,CRISPR,Cas9,HDR,NHEJ,homology,directed,repair,nonhomologous,end,joining,CRISPR,Reagents,CRISPR,Reagents,TocrisBioscience

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Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。

Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。

Tocris Bioscience的主要产品包括：

Small Molecules

Peptides

Aptamers

Controlled Substances

Compound Libraries

DREADD Ligands

Fluorescent Imaging

Ligand Sets

Optopharmacology

Reagents

Toxins