首页 > Tocris > Tocris/Clozapine N-oxide/4936/50/50 mg

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Tocris/Clozapine N-oxide/4936/50/50 mg

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4936/50

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Description:ActivatorofmuscarinicDREADDsChemicalName:8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepinePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityMetaboliteofclozapine(Cat.No.0444).Activateshumanmuscarinicdesignerreceptors(DREADDs)invitro.SilenceshippocampalneuronsexpressinghM4DREADDsinvitro.ActivatesGs-linkedDREADDS-AgRPinmiceviaintracerebroventricular(i.c.v)injection.ShowntobeaP-glycoprotein(P-gp)effluxpumpsubstrate.Watersolublesalt(Cat.No.6329)alsoavailable.OtherpotentandselectivehM3DqDREADDagoNISTsavailable:DREADDagonist21(Cat.No.5548)andPerlapine(Cat.No.5549)TechnicalDataM.Wt342.82FormulaC18H19ClN4OStorageStoreatRTPurity≥99%(HPLC)CASNumber34233-69-7PubChemID2819InChIKeyWYRDWWAASBTJLM-UHFFFAOYSA-NSmilesClC(C=C3)=CC1=C3NC(C=CC=C2)=C2C(N4CC[N+](C)([O-])CC4)=N1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO6.8620ethanol3.4310mMwithgentlewarmingPreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight342.82.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.92mL14.58mL29.17mL5mM0.58mL2.92mL5.83mL10mM0.29mL1.46mL2.92mL50mM0.06mL0.29mL0.58mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Eiermannetal(1997)TheinvolvementofCYP1A2andCYP3A4inthemetabolismofclozapine.Br.J.Clin.Pharmacol.44439PMID:9384460Armbrusteretal(2007)EvolvingthelocktofitthekeytocreateafamilyofGprotein-coupledreceptorspotentlyactivatedbyaninertligand.Proc.Natl.Acad.Sci.U.S.A.1045163PMID:17360345Zamanetal(2014)LMO4isessentialforparaventricularhypothalamicneuronalactivityandcalciumchannelexpressiontopreventhyperphagia.J.Neurosci.34140PMID:24381275Gomezetal(2017)Chemogeneticsrevealed:DREADDoccupancyandactivationviaconvertedclozapine.Science357503PMID:28774929Nakajimaetal(2016)Gs-coupledGPCRsignallinginAgRPneuronstriggerssustainedincreaseinfoodintake.Nat.Commun.810268PMID:26743492Rothetal(2016)DREADDsforNeuroscientistsNeuron89683PMID:26889809Keywords:ClozapineN-oxide,supplier,clozapine,metabolite,5HT2A/2C,non-selective,receptors,SEROtonin,5HT2C,5HT2,5HT2A,dopaminergic,dopamine,antagonists,D4,clozapine-N-oxide,DREADDs,DREADD,Ligands,muscarnic,receptors,designer,receptors,CNO,Non-selective,Dopamine,5-HT2A,Receptors,5-HT2C,Receptors,DREADDs,Glutamate,(Metabotropic),Group,III,Receptors,Glutamate,(Metabotropic),Group,II,Receptors,Multidrug,Transporters,DREADDs,TocrisBioscience

Tocris Bioscience.png

Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。

Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。

Tocris Bioscience的主要产品包括：

Small Molecules

Peptides

Aptamers

Controlled Substances

Compound Libraries

DREADD Ligands

Fluorescent Imaging

Ligand Sets

Optopharmacology

Reagents

Toxins