Description:PotentandselectivehM3DqDREADDagoNISTChemicalName:6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepinePurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityPotentandselectivehM3DqDREADDagonist(EC50=2.8nM).Exhibits>10,000-foldselectivityforhM3DqoverhM3.TechnicalDataM.Wt291.39FormulaC19H21N3StorageStoreatRTPurity≥99%(HPLC)CASNumber1977-11-3PubChemID16106InChIKeyPWRPUAKXMQAFCJ-UHFFFAOYSA-NSmilesCN(CC4)CCN4C1=NC(C=CC=C3)=C3CC2=C1C=CC=C2Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO14.5750ethanol14.5750water1.465mMwithgentlewarmingPreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight291.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM3.43mL17.16mL34.32mL5mM0.69mL3.43mL6.86mL10mM0.34mL1.72mL3.43mL50mM0.07mL0.34mL0.69mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Chenetal(2015)Thefirststructure-activityrelationshipstudiesfordesignerreceptorsexclusivelyactivatedbydesignerdrugs.ACSChem.Neurosci.6476PMID:25587888Keywords:Perlapine,supplier,Perlapine,potent,selective,hM3Dq,DREADD,agonists,antagonism,designer,receptors,drugs,muscarinic,receptors,activators,DREADDs,M3,Receptors,DREADDs,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
