Description:PhotoswitchableKvchannelblockerChemicalName:N,N,N-Triethyl-2-oxo-2-[[4-[2-[4-[(1-oxo-2-propen-1-yl)amino]phenyl]diazenyl]phenylamino]ethanaminiumchloridePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityPhotoswitchableKvchannelblocker(IC50valuesare2and64μMat500nmand380nmrespectively).Switchesconformationfromcistotransat500nmandtranstocisat380nm.ExhibitsminimalactivityatNav1.2andL-typeCa2+channels.Stimulatesactionpotentialfiringofhippocampalneuronsinvitroat500nmandrestoresvisualresponsivenessinblindmiceat380nm.LicensingInformationSoldunderlicensefromPhotoswitchBiosciences,Inc.TechnicalDataM.Wt443.97FormulaC23H30ClN5O2StorageStoreat-20°CPurity≥98%(HPLC)PubChemID91826090InChIKeyCTVKLIGDHHKPIB-UHFFFAOYSA-NSmilesO=C(C=C)NC(C=C2)=CC=C2/N=N/C1=CC=C(NC(C[N+](CC)(CC)CC)=O)C=C1.[Cl-]Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO8.8820PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight443.97.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.25mL11.26mL22.52mL5mM0.45mL2.25mL4.5mL10mM0.23mL1.13mL2.25mL50mM0.05mL0.23mL0.45mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Fortinetal(2008)PhotochemicalcontrolofendogenousionchannelsandcellularexcitABIlity.Nat.Methods5331PMID:18311146Polosukhinaetal(2012)Photochemicalrestorationofvisualresponsesinblindmice.Neuron75271PMID:22841312Banghartetal(2009)Photochromicblockersofvoltage-gatedpotassiumchannels.Angew.Chem.Int.Ed.489097PMID:19882609Keywords:AAQchloride,supplier,selective,photoswitchable,Kv,potassium,channels,K+,blockers,ligands,Photoswitchable,Ligands,Voltage-Gated,Potassium,Channels,Photoswitchable,Ligands,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
