Description:PhotoswitchableTRPV1channelblockerChemicalName:1,3,4,5-Tetrahydro-7,8-dihydro-N-[2-[4-[2-[4-(trifluoromethyl)phenyl]diazenyl]phenyl]ethyl]-2H-2-benzazepine-2-carbothioamidePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityPhotoswitchableTRPV1channelblocker(IC50=3.1μM).ActsasanantagoNISTintransconformationduringvoltagegatedactivation.Alsoactsasanantagonistinthecisformationduringcapsaicin-inducedTRPV1currents.Switchesconformationfromcistotransat440nmandtranstocisat360nm.Allowsphotoswitchableantagonistandanagonisttobeappliedatthesametime.TechnicalDataM.Wt514.56FormulaC26H25F3N4O2SStorageStoreat-20°CPurity≥98%(HPLC)CASNumber1459809-09-6PubChemID121513863InChIKeyCOPZFJSJZPCWFD-UHFFFAOYSA-NSmilesS=C(NCCC3=CC=C(/N=N/C4=CC=C(C(F)(F)F)C=C4)C=C3)N(CCC2)CC1=C2C=C(O)C(O)=C1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO51.46100water10.2920mMwithgentlewarmingPreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight514.56.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM1.94mL9.72mL19.43mL5mM0.39mL1.94mL3.89mL10mM0.19mL0.97mL1.94mL50mM0.04mL0.19mL0.39mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Steinetal(2013)OpticalcontrolofTRPV1channels.Angew.Chem.Int.Ed.Engl.529845PMID:23873837Keywords:AC4,supplier,Photoswitchable,TRPV1,channel,blockers,transient,receptor,potential,vanilloids,ligands,Photoswitchable,Ligands,TRPV,Photoswitchable,Ligands,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
