Description:PotentCK1δ/εinhibitorChemicalName:4-[4-(4-Fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-2-pyrimidinaminePurity:≥98%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivityPotentcasesinkinase1δ/εinhibitor(IC50valuesare3.9and17nM,respectively).MediatescircADIanrhythmphase-delayingeffectsinvivo.Attenuatesopioiddrugseekingbehaviourinaddictioninvivomodels.LicensingInformationSoldforresearchpurposesunderagreementfromPfizerInc.TechnicalDataM.Wt419.46FormulaC22H22FN7OStorageStoreat+4°CPurity≥98%(HPLC)CASNumber1293395-67-1PubChemID51353555InChIKeyXPWHRQHBPRSUAW-UHFFFAOYSA-NSmilesNC1=NC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCN(CC5=NOC=C5)CC4)=CC=N1Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO41.95100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight419.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.38mL11.92mL23.84mL5mM0.48mL2.38mL4.77mL10mM0.24mL1.19mL2.38mL50mM0.05mL0.24mL0.48mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Wageretal(2014)Caseinkinase1δ/εinhibitorPF-5006739attenuatesopioiddrug-seekingbehavior.ACSChem.Neurosci.51253PMID:25299732Keywords:PF5006739,supplier,PF5006739,Casesin,kinase,1δ/ε,delta,epsilon,inhibitors,inhibits,circadian,rhythm,opioid,drug,seeking,behaviour,addiction,Casein,Kinase,1,Casein,Kinase,1,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
